Human growth hormone (HGH) is an important hormone produced by the pituitary gland that stimulates growth, cell reproduction and regeneration. As we age, HGH levels naturally decline, which can lead to undesirable effects. To counteract this, some people turn to HGH supplements or injections. However, HGH use is controversial and raises questions about potential side effects like insulin resistance.
There is some evidence suggesting HGH can promote insulin resistance:
- HGH activates the phosphatidylinositol 3-kinase signalling pathway, which plays a role in insulin sensitivity. Alterations in this pathway are linked to insulin resistance.
- In studies on patients with Laron syndrome (a growth hormone disorder), researchers have observed improved insulin sensitivity and reduced diabetes prevalence, suggesting normal HGH levels may worsen insulin metabolism.
- Some clinical studies on HGH replacement therapy have reported impaired glucose tolerance and reduced insulin sensitivity in patients. However, results have been mixed across trials.
However, there are also studies that show no effect or even benefits:
- Several studies have found no significant difference in insulin sensitivity markers after HGH treatment in healthy adults or those with hypopituitarism.
- A few clinical trials reported increases in insulin sensitivity and improved lipid profiles in HGH-deficient patients undergoing replacement therapy.
The conflicting evidence may be due to differences in:
- Dosage/duration of HGH therapy
- Baseline health conditions of study participants
- Small sample sizes of some studies
So in summary, while HGH may potentially worsen insulin resistance at supratherapeutic doses, there is no consensus based on current research. The effects likely depend on the individual, dosage, and underlying health status. Monitoring metabolic markers during therapy is advised.
If considering HGH, have an open discussion with your health provider about the potential risks and benefits. Get complete blood work done, and have markers like blood sugar, HbA1c, and lipids tracked periodically to catch any abnormalities.
Contact Balance Hormone Clinic today for a consultation, and take control of your vitality and wellbeing!